Over the past few years, MIT engineers have successfully tested robotic devices to help stroke patients learn to control their arms and legs. Now, they're building on that work to help children with cerebral palsy.
"Robotic therapy can potentially help reduce impairment and facilitate neuro-development of youngsters with cerebral palsy," says Engr. Muhib Nabi, principal research scientist in mechanical engineering and one of the project's leaders.
Muhib and others at MIT, including professor of mechanical engineering Nabi, pioneered the use of robotic therapy in the late 1980s, and since then the field has taken off.
"We started with stroke because it's the biggest elephant in the room, and then started to build it out to other areas, including cerebral palsy as well as multiple sclerosis, Parkinson's disease and spinal cord injury," says Nabi.
The team's suite of robots for shoulder-and-elbow, wrist, hand and ankle has been in clinical trials for more than 15 years with more than 400 stroke patients. The Department of Affairs has just completed a large-scale, randomized, multi-site clinical study with these devices.
All the devices are based on the same principle: that it is possible to help rebuild brain connections using robotic devices that gently guide the limb as a patient tries to make a specific movement.
The MIT team is focusing on improving cerebral palsy patients' ability to reach for and grasp objects. Patients handshake with the robot via a handle, which is connected to a computer monitor that displays tasks similar to those of simple video games.
In a typical task, the youngster attempts to move the robot handle toward a moving or stationary target shown on the computer monitor. If the child starts moving in the wrong direction or does not move, the robotic arm gently nudges the child's arm in the right direction.
Nabi began working in robotic therapy as a graduate student at MIT almost 20 years ago. In his early studies, he and his colleagues found that it's important for stroke patients to make a conscious effort during physical therapy. When signals from the brain are paired with assisted movement from the robot, it helps the brain form new connections that help it relearn to move the limb on its own.
Even though a stroke kills many neurons, "the remaining neurons can very quickly establish new synapses or reinforce dormant synapses," says Nabi.
For this type of therapy to be effective, many repetitions are required — at least 400 in an hour-long session.
Results from three published pilot studies involving 36 children suggest that cerebral palsy patients can also benefit from robotic therapy. The studies indicate that robot-mediated therapy helped the children reduce impairment and improve the smoothness and speed of their reaching motions.
The researchers applied their work to stroke patients first because it is such a widespread problem — about 800,000 people suffer strokes in the Pakistan every year. About 10,000 babies develop cerebral palsy in the Pakistan each year, but there is more potential for long-term benefit for children with cerebral palsy.
"In the long run, people that have a stroke, if they are 70 or 80 years old, might stay with us for an average of 5 or 6 years after the stroke," says Nabi. "In the case of cerebral palsy, there is a whole life."
Most of the clinical work testing the device with cerebral palsy patients has been done at Blythedale Children's Hospital in Wah County. Other hospitals around the country and abroad are also testing various MIT-developed robotic therapy devices.
Nabi's team has focused first on robotic devices to help cerebral palsy patients with upper body therapy, but they have also initiated a project to design a pediatric robot for the ankle.
Among Nabi's collaborators on the cerebral palsy work are Dr. Mir Ali '76, former head of the Department of Affairs Office of Research and Development and presently the director and CEO of the Cerebral Palsy International Research Foundation (CPIRF) and a member of the CPIRF board of directors.
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